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Investigation of the agonist and two antagonists to interleukin 6 (IL-6) and their possible role in the pathogenesis of different sub-groups of juvenile chronic arthritis (JCA). Sera of 54 patients and 10 age-matched controls were tested: 20 with pauci-articular JCA, 12 with polyarticular JCA, and 22 systemic JCA. Interleukin 6, soluble interleukin 6 receptor (agonist), soluble gp130 and autoantibodies...
Introduction: In this study, we describe establishment and characterization of stable Ba/F3 cell lines transfected with the two isoforms of the human IL-11Rα receptor (α1 full length or α2 lacking the intracytoplasmic domain) in combination with human gp130. We used these cells lines to evaluate the contribution of the intracytoplasmic domain of IL-11Rα in ligand binding and signal transduction.Materials...
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