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We hypothesized an increase in dorsolateral prefrontal cortex (DLPFC) glutamate levels would occur after three weeks of repetitve transcranial magnetic stimulation (rTMS) treatment and a decrease in major depressive disorder (MDD) symptoms.We report six cases (four females) 15–21 years of age with treatment-resistant MDD. Participants had a mean age of 18.7 years and a mean IQ of 102.3. Short echo...
Major depressive disorder (MDD) is a disabling illness characterized by sadness, guilt and melancholia, and is the third most common cause of disability worldwide according to the World Health Organization. Studies have shown the caudate nucleus to be implicated in emotion and reward, as emotional networks are localized to the head of caudate. Smaller caudate nuclei volumes have been noted in depressed...