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Immunodominance is an important feature of antiviral, antitumor, and antibacterial cellular immune responses, but it is not well demonstrated in the immune responses against Helicobacter pylori. Antigen-specific CD4 + T cells protect mice against infection with H pylori. We investigated the immunodominant CD4 + T-cell response to neuraminyllactose-binding hemagglutinin (HpaA), which...
Vaccine-mediated Th1-biased CD4+ T cell responses have been shown to be crucial for protection against Helicobacter pylori (H. pylori). In this study, we investigated whether a vaccine composed of CD4+ T cell epitopes together with Th1 adjuvants could confer protection against H. pylori in a mouse model. We constructed an epitope-based vaccine, designated Epivac, which was composed of predicted immunodominant...
This paper aims to study new effective modeling and reasoning techniques, concept evaluation approaches in conceptual design of mechanisms. First, the axiomatic design (AD), set theory and fuzzy logic are introduced and their relationships are analyzed from the viewpoint of application in conceptual design of mechanisms. Second, the problem space and solution space are formalized based on set theory...
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