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Non‐Technical Summary Blood flow in the kidney is tightly regulated. This so‐called autoregulation is essential for the function of the kidney as well as for its protection against damage and failure from high blood pressure. Autoregulation is caused by three mechanisms. The signalling molecule nitric oxide (NO) modulates the balance of these mechanisms, blunting the contribution of the fastest mechanism...
Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, β-galactosidase-labeled axons are absent from the corpus callosum...
Vertebrate skeletogenesis involves two processes, skeletal patterning and osteoblast differentiation. Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage. Satb2 −/− mice exhibit both craniofacial abnormalities that resemble those observed in humans carrying a translocation in SATB2 and defects in osteoblast differentiation...
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