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MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8 + T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8 + T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8 + T cells was severely reduced during acute and chronic viral infections and control of virus...
With the rapid growth in our understanding of tissue-selective lymphocyte trafficking, the complexity of this phenomenon has begun to unravel. It is now becoming clear that effector and memory T cells are endowed with a topographical memory of the site of primary antigen encounter. During activation of naive T cells in secondary lymphoid tissues, a combinatorial access code of adhesion molecules and...
The incorporation of human immunodeficiency virus-type-2 (HIV-2) envelope glycoprotein into murine leukemia virus (MuLV) particles was studied in a transient transfection packaging cell system. We observed that wild-type HIV-2 envelope protein or a frameshift mutant with 187 unrelated carboxyl-terminal residues did not allow the formation of infectious retroviral particles. In view of recent findings...
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