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We investigated the basis for previous observations that fluorescent-labeled neuropeptide Y (NPY) is usually released within 200 ms after fusion, whereas labeled tissue plasminogen activator (tPA) is often discharged over many seconds. We found that tPA and NPY are endogenously expressed in small and different subpopulations of bovine chromaffin cells in culture. We measured the mobility of these...
It is often assumed that upon fusion of the secretory granule membrane with the plasma membrane, lumenal contents are rapidly discharged and dispersed into the extracellular medium. Although this is the case for low-molecular-weight neurotransmitters and some proteins, there are numerous examples of the dispersal of a protein being delayed for many seconds after fusion. We have investigated the role...
α-Latrotoxin and its plasma membrane receptors cause a number of distinct effects in secretory cells. First, by tethering α-latrotoxin to the plasma membrane, CIRL/latrophilin and neurexin 1α facilitate α-latrotoxin-induced channel formation. The stimulation of secretion by α-latrotoxin in neuroendocrine cells is a consequence of Ca 2+ influx through these α-latrotoxin-induced channels...
α-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin Iα was previously described as a high affinity α-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of α-latrotoxin with neurexin Iα cannot explain how α-latrotoxin stimulates neurotransmitter release...
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