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Absence of functional FMRP causes Fragile X syndrome. Abnormalities in synaptic processes in the cerebral cortex and hippocampus contribute to cognitive deficits in Fragile X patients. So far, the potential roles of cerebellar deficits have not been investigated. Here, we demonstrate that both global and Purkinje cell-specific knockouts of Fmr1 show deficits in classical delay eyeblink conditioning...
Cerebellar granule cells constitute the largest neurone population of the brain. Their axons run as parallel fibres along the coronal axis, and the one-dimensional spread of excitation that is expected to result from this arrangement is a key assumption of theories of cerebellar function. In many studies using various techniques, however, it was not possible to evoke such a beam-like propagation of...
In an investigation into the transformation of mossy fiber input to Purkinje cell output in the cerebellar cortex, we have developed a network model including a sophisticated compartmental model of the Purkinje cell. Analysis and simulations demonstrated the need to include a large number of parallel fibers (244000) to obtain realistic Purkinje cell firing patterns for random mossy fiber input. Using...
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