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Meningococcal disease incidence is highest in young children, yet a tetravalent conjugate vaccine is currently not available for this age group. This study evaluated a single dose of four different ACWY-TT conjugate vaccine formulations in 240 toddlers (12–14months) and 268 children (3–5years) compared to licensed age-appropriate control vaccines. In toddlers, rSBA-MenC GMTs for the selected formulation...
To assess immunogenicity, antibody persistence, immune memory, and reactogenicity of a novel heptavalent DTPw–HBV/Hib–MenAC (diphtheria, tetanus, whole cell pertussis–hepatitis B virus/Haemophilus influenzae type b–Neisseria meningitidis serogroups A and C) vaccine.This was an open, randomized study in the Philippines, with DTPw–HBV/Hib–MenAC administered at 6, 10, and 14 weeks of age. Three different...
During a randomised controlled trial with the 23-valent pneumococcal vaccine in older persons, antibody concentrations and opsonophagocytic activity (OPA) were compared between eight patients who developed culture-verified pneumococcal pneumonia and 38 controls, matched for age, sex and vaccination status. Patients who developed pneumococcal pneumonia did not respond with a significant increase of...
Adsorption of the pertussis antigens, pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) onto aluminium phosphate rather than aluminium hydroxide leads to a lower humoral response and poorer protection against intranasal pertussis challenge in mice. These effects could be reversed by inclusion of fimbriae (FIM) 2 and 3 in the formulation. These data emphasis the importance...
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