Search results for: Doudou Huang

Items from 1 to 15 out of 15 results

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Safe‐by‐Design Exfoliation of Niobium Diselenide Atomic Crystals as a Theory‐Oriented 2D Nanoagent from Anti‐Inflammation to Antitumor

Zhaohua Miao, Doudou Huang, Yichuan Wang, Wei‐Jian Li, more

Advanced Functional Materials > 30 > 40 > n/a - n/a

The accompanying relationship between tumor and inflammation raises the concept of concurrent antitumor and anti‐inflammation treatment in the clinic. Despite the wide application of 2D atomic crystals for cancer theranostics, their anti‐inflammation function has been rarely explored. Herein, it is reported that niobium diselenide nanosheets (NbSe₂ NSs), a “star” 2D superconducting atomic crystal,...

article

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Zhaohua Miao, Peiying Liu, Yichuan Wang, Kai Li, more

Small > 15 > 41 > n/a - n/a

Elemental tantalum is a well‐known biomedical metal in clinics due to its extremely high biocompatibility, which is superior to that of other biomedical metallic materials. Hence, it is of significance to expand the scope of biomedical applications of tantalum. Herein, it is reported that tantalum nanoparticles (Ta NPs), upon surface modification with polyethylene glycol (PEG) molecules via a silane‐coupling...

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Depth‐Resolved Enhanced Spectral‐Domain OCT Imaging of Live Mammalian Embryos Using Gold Nanoparticles as Contrast Agent

Yali Huang, Minghui Li, Doudou Huang, Qi Qiu, more

Small > 15 > 35 > n/a - n/a

High‐resolution and real‐time visualization of the morphological changes during embryonic development are critical for studying congenital anomalies. Optical coherence tomography (OCT) has been used to investigate the process of embryogenesis. However, the structural visibility of the embryo is decreased with the depth due to signal roll‐off and high light scattering. To overcome these obstacles,...

article

Emerging therapeutic modalities of PARP inhibitors in breast cancer

Xin Wang, Yaqin Shi, Doudou Huang, Xiaoxiang Guan

Cancer Treatment Reviews > 2018 > 68 > C > 62-68

Inhibition of Poly (ADP-ribose) polymerase (PARP) has shown marked benefit for breast cancer with homologous recombination deficiency, whether driven by defects in BRCA1, BRCA2, or other pathway components. Since the initial approval of olaparib, a mostly investigated PARP inhibitor (PARPi), the clinical development of PARPi in breast cancer treatment has been a major emphasis. Researches in investigating...

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Potential biomarkers of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer

Hehui Fang, Doudou Huang, Fang Yang, Xiaoxiang Guan

Breast Cancer Research and Treatment > 2018 > 168 > 2 > 287-297

PurposeCyclin D/cyclin-dependent kinase 4/6 (CDK4/6) complex inhibitors have recently been proven effective when combined with endocrine therapy in clinical trials. However, the clinical benefit from CDK4/6 inhibitor varied from different patients. In order to optimize the clinical application of CDK4/6 inhibitors, this review focuses on the potential biomarkers applicable to identify patients who...

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Mechanisms of resistance to selective estrogen receptor down-regulator in metastatic breast cancer

Doudou Huang, Fang Yang, Yucai Wang, Xiaoxiang Guan

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer > 2017 > 1868 > 1 > 148-156

Based on the prominent role estrogen receptor (ER) plays in breast cancer, endocrine therapy has been developed to block the ER pathway and has shown great effectiveness. Fulvestrant, the first selective ER down-regulator (SERD), was demonstrated to completely suppress ERα and notably efficient. However, resistance to fulvestrant occurs, either intrinsic or acquired during the treatment. Several potential...

article

Escherichia coli inactivation by pressurized CO2 treatment methods at room temperature: Critical issues

Yongji Zhang, Doudou Huang, Lingling Zhou

Journal of Environmental Sciences > 2016 > 43 > C > 285-292

This study aims to increase the inactivation efficiency of CO₂ against Escherichia coli under mild conditions to facilitate the application of pressurized CO₂ technology in water disinfection. Based on an aerating-cycling apparatus, three different treatment methods (continuous aeration, continuous reflux, and simultaneous aeration and reflux) were compared for the same temperature, pressure (0.3–0...

article

Anti-inflammatory effects of the extract of Gnaphalium affine D. Don in vivo and in vitro

Doudou Huang, Yanhong Chen, Wansheng Chen, Ying Liu, more

Journal of Ethnopharmacology > 2015 > 176 > Complete > 356-364

Gnaphalium affine D. Don (GA) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic mechanism of GA has still not been demonstrated. This study aims to reveal the anti-inflammatory activity and anti-arthritic mechanism of ethanol extract of G. affine D. Don.Anti-inflammatory potential of GA was analyzed...

article

Brevistylumsides A and B, diterpene glycosides from Illicium brevistylum

Yanhong Chen, Zhiying Dong, Doudou Huang, Wansheng Chen, more

Phytochemistry Letters > 2015 > 14 > Complete > 27-30

A phytochemical investigation of 80% ethanol extract of Illicium brevistylum (Illiciaceae) resulted in the isolation of two new diterpene glycosides (1 and 2), together with three known diterpenes (3–5). The structures of the new compounds were deduced on the basis of comprehensive spectroscopic analysis including IR, HR-ESI–MS, ¹H NMR, ¹³C NMR, DEPT, COSY, HMBC and HSQC. The structures of known compounds...

article

Prenylated phenylpropanoid compounds from the stem bark of Illicium burmanicum

Doudou Huang, Haiying Zhu, Yanhong Chen, Wansheng Chen, more

Fitoterapia > 2015 > 107 > C > 22-28

Ten new prenylated phenylpropanoid compounds, burmanicumols A–G (1–6) and illifrognones D–G (7–10), and seven known prenylated phenylpropanoid compounds, were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined on the basis of 1D and 2D NMR, HRESIMS, and CD experiments. Compounds 3, 8, 10, and 14 were moderately potent inhibitors of the NF-κB pathway,...

article

Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense

Doudou Huang, Yun Jiang, Wansheng Chen, Fengyan Yao, more

Journal of Ethnopharmacology > 2015 > 163 > Complete > 256-263

Penthorum chinense Pursh has a long history of use as a health food and folk medicine to alleviate “heat”-associated disorders, promote circulation and diuresis, and to treat liver problems, and to protect the spleen. In this study we provide experimental evidence for the clinical use of Penthorum chinense in the treatment of diabetes mellitus. The aim of the study was to investigate the hypoglycemic...

article

The capillary outward flow inside pinned drying droplets

Doudou Huang, Liran Ma, Xuefeng Xu

International Journal of Heat and Mass Transfer > 2015 > 83 > C > 307-310

In this paper, a theoretical model is introduced and an analytical expression is obtained for the height-averaged velocity of the outward flow inside thin drying droplets for the case the convective Marangoni flow exists. The velocity is also measured by tracking the motion of fluorescent microspheres in the drying droplets. The experimental observations show that a region of constant height-averaged...

article

New phenolic glycosides isolated from Penthorum chinense Pursh

Doudou Huang, Yun Jiang, Wansheng Chen, Fengyan Yao, more

Phytochemistry Letters > 2015 > 11 > Complete > 163-167

A phytochemical investigation from 80% ethanol extract of Penthorum chinense Pursh (Saxifragaceae) resulted in the isolation of three new phenolic glycosides (1–3), together with three known phenolic glycosides (4–6). The structures of the new compounds were deduced from their comprehensive spectroscopic analysis including IR, HR-EI-MS, ¹ H NMR, ¹³ C NMR, DEPT, COSY, HMBC and HMQC...

article

Linear growth of colloidal rings at the edge of drying droplets

Xuefeng Xu, Liran Ma, Doudou Huang, Jianbin Luo, more

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2014 > 447 > Complete > 28-31

The ring-like deposit along the perimeter of drying droplets is commonly observed, and its formation process is crucial to the applications attempting to promote or attenuate this phenomenon. In this paper, the growth of colloidal rings formed at the edge of drying droplets has been measured by utilizing fluorescent colloidal particles. The experimental observations indicate a nearly linear growth...

article

Four new sesquiterpene lactones from the stem bark of Illicium burmanicum

Doudou Huang, Huaping Deng, Wansheng Chen, Guanghui Huang, more

Fitoterapia > 2014 > 92 > Complete > 194-199

Four new sesquiterpene lactones (1), (2), (3), and (4), along with three known sesquiterene, namely, 6,7,10-trihydoxyisodaucane (5), 4β,10β-dihydroxyaromadendrane (6), and sescrassidiol (7) were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined using 1D and 2D NMR, and HRESIMS. The anti-inflammatory activities of these compounds were evaluated...

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