Yi-Juai Chen

article

Elevated transglutaminase-2 expression mediates fibrosis in areca quid chewing-associated oral submucocal fibrosis via reactive oxygen species generation

Shiuan-Shinn Lee, Yi-Juai Chen, Chung-Hung Tsai, Fu-Mei Huang, more

Clinical Oral Investigations > 2016 > 20 > 5 > 1029-1034

Objectives Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a role in the pathogenesis of areca quid chewing-associated OSF and arecoline, a major...

article

Effects of arecoline on cell growth, migration, and differentiation in cementoblasts

Yi-Juai Chen, Shiuan-Shinn Lee, Fu-Mei Huang, Hui-Chieh Yu, more

Journal of Dental Sciences > 2015 > 10 > 4 > 388-393

Studies have supported a higher prevalence of periodontal disease among areca quid chewers than non-chewers. However, few studies have stated the effects of areca quid on periodontal tissues. The aim of this study was to investigate the inhibitory effects of arecoline, the major alkaloid of areca nut, on murine immortalized cementoblast cell line (OCCM.30).Cytotoxicity was judged using tetrazolium...

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Effects of nicotine on differentiation, prostaglandin E2, and nitric oxide production in cementoblasts

Yi-Juai Chen, Shiuan-Shinn Lee, Fu-Mei Huang, Yu-Chao Chang

Journal of Dental Sciences > 2015 > 10 > 4 > 431-436

Cigarette smoking is an important risk factor in the pathogenesis of periodontal disease. Little is known about the effects of nicotine, the major component of cigarette smoke, on cementoblasts. The aim of this study was to investigate the cytopathologic effects of nicotine on murine immortalized cementoblast cell line (OCCM.30).Cell viability was judged by using the tetrazolium bromide reduction...

article

BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer

Chun-Yi Chuang, Jai-Nien Tung, Mao-Chang Su, Buor-Chang Wu, more

Archives of Oral Biology > 2013 > 58 > 1 > 102-109

Most reports have shown that PAH-related DNA adducts are positively correlated with the smoking status of oral cancer patients. However, these reports did not focus on a specific carcinogen in cigarette smoke. The purpose of this study was to elucidate the role of the BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)–DNA adduct in the development of oral cancer in Taiwanese patients...

article

Nevoid basal cell carcinoma syndrome—case report and genetic study

Yu-Feng Huang, Yi-Juai Chen, Hui-Wen Yang

Journal of Dental Sciences > 2010 > 5 > 3 > 166-170

Nevoid basal cell carcinoma syndrome (also named Gorlin-Goltz syndrome) is a rare disease. Commonly seen features include multiple odontogenic keratocysts (OKCs), nevus-like basal cell carcinoma, and bifid ribs. Genetic alterations of the PTCH1 gene are associated with the disease. Herein, we report the case of a 15-year-old girl who presented with multiple OKCs, a bifid rib, ectopic calcification...

article

The use of bioimpedance in the detection/screening of tongue cancer

Tai-Ping Sun, Congo Tak-Shing Ching, Chi-Sheng Cheng, Su-Hua Huang, more

Cancer Epidemiology > 2010 > 34 > 2 > 207-211

Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objectives of this study were therefore to study the electrical properties of cancerous tongue tissue and normal tongue tissue, as well as to investigate a new approach for low-cost, noninvasive, and real-time screening...

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Examination of the Signal Transduction Pathways Leading to Upregulation of Tissue Type Plasminogen Activator by Interleukin-1α in Human Pulp Cells

Fu-Mei Huang, Chung-Hung Tsai, Yi-Juai Chen, Ming-Yung Chou, more

Journal of Endodontics > 2006 > 32 > 1 > 30-33

Tissue type plasminigen activator (t-PA) is one of the important proteolysis factors in the pathogenesis of pulpal inflammation. However, the mechanisms and signal transduction pathways involved in the production of t-PA in human pulp cells are not fully understood. The purpose of this study was to investigate the t-PA activity in human pulp cells stimulated with various pharmacological agents. IL-1α...

article

The Upregulation of Matrix Metalloproteinase-9 in Inflamed Human Dental Pulps

Chung-Hung Tsai, Yi-Juai Chen, Fu-Mei Huang, Ying-Fang Su, more

Journal of Endodontics > 2005 > 31 > 12 > 860-862

The matrix metalloproteinases (MMPs) participate in a wide variety of extracellular matrix degradation. Detailed knowledge of MMPs may be important for understanding the pathogenesis of pulpal inflammation. The purpose of this study was to compare MMP-9 expression in clinically healthy human pulp and inflamed human pulp tissue specimens. We compared the levels of MMP-9 between clinically healthy pulp...

article

The upregulation of insulin-like growth factor-1 in oral submucous fibrosis

Chung-Hung Tsai, Shun-Fa Yang, Yi-Juai Chen, Ming-Yung Chou, more

Oral Oncology > 2005 > 41 > 9 > 940-946

Insulin-like growth factor-1 (IGF-1) is a member of a family of two interacting polypeptide hormone ligands with close homology to proinsulin. IGF-1 can influence mesenchymal cell migration, proliferation, and extracellular matrix deposition, thus implicating it in the progression of fibrotic disorders. Currently, there is limited information about the regulation of IGF-1 expression in areca quid-associated...

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Search results for: Yi-Juai Chen

Elevated transglutaminase-2 expression mediates fibrosis in areca quid chewing-associated oral submucocal fibrosis via reactive oxygen species generation

Effects of arecoline on cell growth, migration, and differentiation in cementoblasts

Effects of nicotine on differentiation, prostaglandin E2, and nitric oxide production in cementoblasts

BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer

Nevoid basal cell carcinoma syndrome—case report and genetic study

The use of bioimpedance in the detection/screening of tongue cancer

Examination of the Signal Transduction Pathways Leading to Upregulation of Tissue Type Plasminogen Activator by Interleukin-1α in Human Pulp Cells

The Upregulation of Matrix Metalloproteinase-9 in Inflamed Human Dental Pulps

The upregulation of insulin-like growth factor-1 in oral submucous fibrosis

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