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Background: Plasma and tissue angiotensin-converting enzyme (ACE) activities are believed to be under genetic control. Increased ACE activity due to the deletion polymorphism of the ACE gene is associated with a wide variety of diseases that exhibit endothelial disturbances. Available reports suggest that the incidence of ACE gene deletion polymorphism associated with preeclampsia varies depending...
Background: Isoprostanes are prostaglandin-like end products of arachidonic acid peroxidation that are produced by a free radical-catalyzed mechanism. Considering its free radical-dependent formation and potent contractor effect, it is postulated that isoprostane 8-iso PGF 2α may play an important role in oxidative stress-related smooth muscle dysfunction. These substances may also influence...
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