Search results for: Tiean Zhou

Items from 1 to 10 out of 10 results

article

A high-throughput QCM chip configuration for the study of living cells and cell-drug interactions

Haibo Shen, Tiean Zhou, Jiajin Hu

Analytical and Bioanalytical Chemistry > 2017 > 409 > 27 > 6463-6473

In this study, we present a novel design of interference-free, negligible installation-induced stress, suitable for the fabrication of high-throughput quartz crystal microbalance (HQCM) chips. This novel HQCM chip configuration was fabricated using eight independent yet same-batch quartz crystal resonators within a common glass substrate with eight through-holes of diameter slightly larger than that...

article

Dynamic cell adhesion and viscoelastic signatures distinguish normal from malignant human mammary cells using quartz crystal microbalance

Tiean Zhou, Kenneth A. Marx, Abiche H. Dewilde, Donna McIntosh, more

Analytical Biochemistry > 2012 > 421 > 1 > 164-171

During transformation of a normal cell to a cell capable of forming a cancerous growth, cellular morphology, the cytoskeleton, and focal contacts undergo significant changes. These changes should be capable of being characterized via real-time monitoring of the dynamic cell adhesion process and viscoelastic properties of cells. Here, we describe use of the quartz crystal microbalance (QCM) to distinguish...

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Electropolymerized tyrosine-based thin films: Selective cell binding via peptide recognition to novel electropolymerized biomimetic tyrosine RGDY films

Kenneth A. Marx, Tiean Zhou, Donna McIntosh, Susan J. Braunhut

Analytical Biochemistry > 2009 > 384 > 1 > 86-95

We have created thin films by cyclic voltammetry (CV) electropolymerizations of the following phenolic functional group-based monomers: phenol; tyrosineamide; the tetrapeptide RGDY-containing the integrin membrane adhesion protein recognition tripeptide RGD; RDGY, a nonsense control tetrapeptide; and 1:3 mixtures of tyrosineamide with the two tetrapeptide monomers. The film formation process and description...

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A comparative study of the cytoskeleton binding drugs nocodazole and taxol with a mammalian cell quartz crystal microbalance biosensor: Different dynamic responses and energy dissipation effects

Kenneth A. Marx, Tiean Zhou, Anne Montrone, Donna McIntosh, more

Analytical Biochemistry > 2007 > 361 > 1 > 77-92

The quartz crystal microbalance (QCM) was used to create piezoelectric whole-cell biosensors utilizing either living endothelial cells (ECs) or the metastatic human mammary cancer cell line MDA-MB-231 adhering to the gold QCM surface under in vitro growth conditions. We utilized the whole-cell QCM biosensors for the detection of the effects of varying concentrations of the microtubule binding drugs...

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Quartz crystal microbalance biosensor study of endothelial cells and their extracellular matrix following cell removal: Evidence for transient cellular stress and viscoelastic changes during detachment and the elastic behavior of the pure matrix

Kenneth A. Marx, Tiean Zhou, Anne Montrone, Donna McIntosh, more

Analytical Biochemistry > 2005 > 343 > 1 > 23-34

A quartz crystal microbalance (QCM) cell biosensor utilizing living endothelial cells (ECs) or human breast cancer cells (MCF-7) adhering to the gold QCM surface was used to study the relative contributions of the cells and their underlying extracellular matrix (ECM) to the measured QCM Δf and ΔR shifts. The ECM represents a natural biomaterial that is synthesized by the cells to enable their attachment...

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Electropolymerized Films Formed from the Amphiphilic Decyl Esters of d - and l -Tyrosine Compared To l -Tyrosine Using the Electrochemical Quartz Crystal Microbalance

Kenneth A. Marx, Tiean Zhou, Dang Long

Biomacromolecules > 2005 > 6 > 3 > 1698 - 1706

article

Comparative study of electropolymerization versus adsorption of tyrosine and the decyl ester of tyrosine on platinum electrodes

Kenneth A. Marx, Tiean Zhou

Journal of Electroanalytical Chemistry > 2002 > 521 > 1-2 > 53 - 60

We compared adsorption versus electropolymerization via cyclic voltammetry (CV) of tyrosine, an amino acid, to that of the decyl ester of d-tyrosine (DEDT), on Pt electrodes. DEDT is an amphiphilic compound, capable of self-assembly into long rod like or tubular aggregate structures. Tyrosine and DEDT differ fundamentally in their interactions with the Pt electrode, affecting their electropolymerization...

article

A quartz crystal microbalance cell biosensor: detection of microtubule alterations in living cells at nM nocodazole concentrations

Kenneth A. Marx, Tiean Zhou, Anne Montrone, Heather Schulze, more

Biosensors and Bioelectronics > 2001 > 16 > 9-12 > 773 - 782

The quartz crystal microbalance (QCM) was used to create a piezoelectric biosensor utilizing living endothelial cells (ECs) as the biological signal transduction element. ECs adhere to the hydrophilically treated gold QCM surface under growth media containing serum. At 24 h following cell addition, calibration curves were constructed relating the steady state Δf and ΔR shift values observed to the...

article

Amperometric hydrogen peroxide sensor electrodes coated with electropolymerized tyrosine derivative and phenolic films

Dang Duc Long, Kenneth A. Marx, Tiean Zhou

Journal of Electroanalytical Chemistry > 2001 > 501 > 1-2 > 107 - 113

Amphiphilic decyl ester derivatives of the amino acids d- and l-tyrosine (DEDT and DELT) self-assemble into long rod-like or tubular aggregate structures in aqueous buffered solutions as visualized by SEM or light microscopy. We demonstrate that electrochemical polymerization of DEDT and DELT at concentrations lower than their critical micelle concentration values, via cyclic potential scanning between...

article

Amperometric hydrogen peroxide sensor electrodes coated with electropolymerized tyrosine derivative and phenolic films

Dang Duc Long, Kenneth A. Marx, Tiean Zhou

Journal of Electroanalytical Chemistry > 2001 > 501 > 1-2 > 107-113

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