Search results for: Denis Hadjiliadis

Items from 1 to 20 out of 40 results

article

Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel

Me‐Linh Luong, Yoshiko Nakamachi, Fernanda P. Silveira, Catherine O. Morrissey, more

Transplant Infectious Disease > 26 > 3 > n/a - n/a

Purpose Antimicrobial misuse contributes to antimicrobial resistance in thoracic transplant (TTx) and mechanical circulatory support (MCS) recipients. This study uses a modified Delphi method to define the expected appropriate antimicrobial prescribing for the common clinical scenarios encountered in TTx and MCS recipients. Methods An online questionnaire on managing 10 common infectious disease...

article

Lung transplantation outcomes after crossing low‐level donor specific antibodies without planned augmented immunosuppression

Andrew M. Courtwright, Malek Kamoun, Joshua M. Diamond, Jane Kearns, more

Clinical Transplantation > 35 > 11 > n/a - n/a

It is unknown whether some donor specific antibodies (DSA) can be crossed at the time of lung transplant without desensitization or augmented induction immunosuppression. This study assessed whether crossing low‐level pre‐transplant DSA (defined as mean fluorescence intensity [MFI] 1000–6000) without augmented immunosuppression is associated with worse retransplant‐free or chronic lung allograft dysfunction...

article

Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology

Blandine Rammaert, Mathieu Puyade, Oliver A. Cornely, Danila Seidel, more

Transplant Infectious Disease > 21 > 5 > n/a - n/a

Background Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international...

article

Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis

Gina Hong, Noah Lechtzin, Denis Hadjiliadis, Steven M. Kawut

Pediatric Pulmonology > 54 > 2 > 133 - 140

Introduction Prevalence of fungi has been rising in the cystic fibrosis (CF) population. Scedosporium species (spp) is the second most common mold seen in the CF respiratory tract. However, the characteristics associated with Scedosporium isolation and its clinical implications are poorly understood. The goal of this study was to determine clinical factors associated with Scedosporium spp to better...

article

β‐Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1‐hour oral glucose tolerance test glucose ≥155 mg/dL

Sarah C Nyirjesy, Saba Sheikh, Denis Hadjiliadis, Diva D De Leon, more

Pediatric Diabetes > 19 > 7 > 1173 - 1182

Background Patients with pancreatic insufficient cystic fibrosis (PI‐CF) meeting standard criteria for normal glucose tolerance display impaired β‐cell secretory capacity and early‐phase insulin secretion defects. We sought evidence of impaired β‐cell secretory capacity, a measure of functional β‐cell mass, among those with early glucose intolerance (EGI), defined as 1‐hour oral glucose tolerance...

article

Gastrointestinal cancers in patients with cystic fibrosis

Patrick Maisonneuve, Albert B Lowenfels, Denis Hadjiliadis, Alexander Khoruts, more

The Lancet Oncology > 2018 > 19 > 8 > e368

article

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations

Denis Hadjiliadis, Alexander Khoruts, Ann G. Zauber, Sarah E. Hempstead, more

Gastroenterology > 2018 > 154 > 3 > 736-745.e14

Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5−10 times greater compared to the general population, and 25−30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendations...

article

New Comorbidities in the Changing Face of Cystic Fibrosis Care

Michael Bonk, Michael M. Rey, Denis Hadjiliadis

Journal of Cystic Fibrosis > 2017 > 16 > 6 > 647-648

article

Using Epidemiologic Evidence to Guide Recommendations for Colorectal Cancer Screening in Adults with Cystic Fibrosis

Ann G. Zauber, Andrea Gini, Alexander Khoruts, Denis Hadjiliadis, more

Annals of Epidemiology > 2017 > 27 > 8 > 504

article

Consensus Recommendations for Colorectal Cancer Screening in Adults with Cystic Fibrosis

Alexander Khoruts, Albert B. Lowenfels, Denis Hadjiliadis, Ann G. Zauber, more

Gastroenterology > 2017 > 152 > 5(S1) > S544

article

Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation

Venkateshwar Mutyam, Emily Falk Libby, Ning Peng, Denis Hadjiliadis, more

Journal of Cystic Fibrosis > 2017 > 16 > 1 > 24-29

Premature termination codons (PTCs) in cystic fibrosis transmembrane conductance regulator (CFTR) gene result in nonfunctional CFTR protein and are the proximate cause of ~11% of CF causing alleles. Aminoglycosides and other novel agents are known to induce translational readthrough of PTCs, a potential therapeutic approach. Among PTCs, W1282X CFTR is unique, as it is a C-terminal CFTR mutation that...

article

Contraceptive choices and preferences in a cohort of women with cystic fibrosis

Andrea Hsu Roe, Sarah A. Traxler, Denis Hadjiliadis, Mary D. Sammel, more

Respiratory Medicine > 2016 > 121 > C > 1-3

As life expectancy for women with cystic fibrosis (CF) improves, reproductive decision-making is becoming increasingly relevant. We sought to characterize fertility intentions, contraceptive use, and preferences among adult females with CF.We conducted a cross-sectional survey of contraceptive use and preferences in reproductive-aged women with CF. Subjects were recruited via an electronic mailing...

article

Gastroparesis Concurrent with Adult Cystic Fibrosis; Are They Related?

Rohan Mandaliya, Denis Hadjiliadis, Sidney Cohen

The American Journal of Medicine > 2016 > 129 > 5 > e21-e22

article

The 2015 International Society for Heart and Lung Transplantation Guidelines for the management of fungal infections in mechanical circulatory support and cardiothoracic organ transplant recipients: Executive summary

Shahid Husain, Amparo Sole, Barbara D. Alexander, Saima Aslam, more

The Journal of Heart and Lung Transplantation > 2016 > 35 > 3 > 261-282

article

Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin

Robert Bucki, Katrina Cruz, Katarzyna Pogoda, Ashley Eggert, more

Journal of Cystic Fibrosis > 2015 > 14 > 5 > 587-593

DNase (Pulmozyme) effectiveness in cystic fibrosis treatment is in some cases limited by its inability to access DNA trapped within bundles in highly viscous fluids that also contain actin. Dissociating DNA-containing bundles using actin depolymerizing agents and polyanions has potential to increase DNase efficacy.Fluorescence measurements of YOYO-1 and a rheological creep-recovery test quantified...

article

Inspiratory muscle strength relative to disease severity in adults with stable cystic fibrosis

Robert L. Dekerlegand, Denis Hadjiliadis, Anne K. Swisher, J. Scott Parrott, more

Journal of Cystic Fibrosis > 2015 > 14 > 5 > 639-645

Due to heterogeneity in pulmonary disease, current literature may misrepresent inspiratory muscle involvement in cystic fibrosis (CF). This study investigated inspiratory muscle strength (IMS) relative to disease severity in adults with CF.Maximal inspiratory pressure (MIP) was assessed in 58 adults with stable CF grouped by disease severity (20 mild, 20 moderate, 18 severe) and compared to 20 controls...

article

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer, Anas Hadeh, Pamela A. Ohman-Strickland, Robert L. Zanni, more

Journal of Cystic Fibrosis > 2015 > 14 > 4 > 497-506

Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF.Enrollees totaled 597. Overall mean...

article

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study

Jason B Turowski, Ralph A Pietrofesa, John A Lawson, Melpo Christofidou-Solomidou, more

BMC Complementary and Alternative Medicine > 2015 > 15 > 1 > 1-14

Background Cystic fibrosis (CF) leads to advanced lung disease despite aggressive care. Persistent inflammation and oxidative stress contribute to exacerbations and disease progression. Flaxseed (FS), a dietary botanical supplement with high fiber, lignan phenolics, and omega-3 fatty acids has anti-inflammatory and antioxidant properties in murine models of acute and chronic lung injury. This pilot...

article

Cystic fibrosis and pregnancy in the modern era: A case control study

Monica Ahluwalia, Jeffrey B. Hoag, Anas Hadeh, Marianne Ferrin, more

Journal of Cystic Fibrosis > 2014 > 13 > 1 > 69-73

Increasingly, women with cystic fibrosis become pregnant. Outcomes of these women need further study particularly in the setting of improved survival in CF.We performed a case-control study of pregnant CF women including 22 matched pairs with an average follow-up of 4.5years. Nutritional outcomes, changes in lung function, and exacerbation rates were compared.Matched pairs were similar in age, sweat...

article

Post-transplant lymphoproliferative disorder after lung transplantation: A review of 35 cases

Brandon E. Kremer, Ran Reshef, Jamal G. Misleh, Jason D. Christie, more

Journal of Heart and Lung Transplantation > 2012 > 31 > 3 > 296-304

Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation. The risk of developing PTLD varies depending on a number of factors, including the organ transplanted and the degree of immunosuppression used. We report a retrospective analysis of 35 patients with PTLD treated at our center after lung transplantation. Of 705 patients who received allografts, 34 (4...

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INFONA - science communication portal

Search results for: Denis Hadjiliadis

Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel

Lung transplantation outcomes after crossing low‐level donor specific antibodies without planned augmented immunosuppression

Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology

Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis

β‐Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1‐hour oral glucose tolerance test glucose ≥155 mg/dL

Gastrointestinal cancers in patients with cystic fibrosis

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations

New Comorbidities in the Changing Face of Cystic Fibrosis Care

Using Epidemiologic Evidence to Guide Recommendations for Colorectal Cancer Screening in Adults with Cystic Fibrosis

Consensus Recommendations for Colorectal Cancer Screening in Adults with Cystic Fibrosis

Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation

Contraceptive choices and preferences in a cohort of women with cystic fibrosis

Gastroparesis Concurrent with Adult Cystic Fibrosis; Are They Related?

The 2015 International Society for Heart and Lung Transplantation Guidelines for the management of fungal infections in mechanical circulatory support and cardiothoracic organ transplant recipients: Executive summary

Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin

Inspiratory muscle strength relative to disease severity in adults with stable cystic fibrosis

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study

Cystic fibrosis and pregnancy in the modern era: A case control study

Post-transplant lymphoproliferative disorder after lung transplantation: A review of 35 cases

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