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To identify cellular components necessary for the intracellular trafficking and/or function of cell surface βPP we screened for proteins that interact with the cytoplasmic domain of βPP using the ''interaction trap''. Employing this strategy, we identified a novel human homologue of the rat FE65 gene, hFE65L. Given the high degree of conservation between βPP and the βPP homologues, APLP1 and APLP2,...