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The N-terminal region of the α integrin subunits is predicted to fold into a β-propeller domain. Using K562 α4 transfectants we show that mutations at α4 subunit residues Gly 130 and Gly 190 affect the conformation of this domain causing a reduction in the recognition of α4 by anti-α4 antibodies which map to the β-propeller. The improper α4 conformation also led...