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In September 2015, NASA selected five mission concepts from a field of 27 to proceed to the next stage (step 2) of the latest Discovery mission competition. Each team submitted a Mission Concept Study to NASA in August 2016, and in January of 2017 NASA selected Psyche and a second mission for flight. This paper describes Psyche, a unique investigation of a metal world, which is the only one of the...
T cell development requires sequential localization of thymocyte subsets to distinct thymic microenvironments. To address mechanisms governing this segregation, we used two-photon microscopy to visualize migration of purified thymocyte subsets in defined microenvironments within thymic slices. Double-negative (CD4 − 8 − ) and double-positive (CD4 + 8 + ) thymocytes...
Granzyme A (GzmA) induces a caspase-independent cell death pathway characterized by single-stranded DNA nicks and other features of apoptosis. A GzmA-activated DNase (GAAD) is in an ER associated complex containing pp32 and the GzmA substrates SET, HMG-2, and Ape1. We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor...
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