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The circadian clock is generated by a molecular timekeeping mechanism coordinating daily oscillations of physiology and behaviors in mammals. In the mammalian circadian clockwork, basic helix–loop–helix ARNT‐like protein 1 (BMAL1) is a core circadian component whose defects lead to circadian disruption and elicit behavioral arrhythmicity. To identify previously unknown regulators for circadian clocks,...
The precise regulation of the T‐cell activation process is critical for overall immune homeostasis. Although protein phosphatase 2A (PP2A) is required for T‐cell development and function, the role of PPP2CB, which is the catalytic subunit β isoform of PP2A, remains unknown. In the present study, using a T cell‐specific knockout mouse of PPP2CB (PPP2CBfl/fl Lck‐Cre+), we demonstrated that PPP2CB was...