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In rodent brown adipose tissue, the β-adrenergic signaling is believed, by an action on PGC-1α, to control UCP1 expression and mitochondriogenesis. We addressed this hypothesis using β 1 /β 2 /β 3 -adrenoceptor knockout (β-less) brown adipocytes in primary culture. In these cells: (a) proliferation and differentiation into multilocular cells were normal; (b) UCP1 mRNA expression...
Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β 1 /β 2 /β 3 ). To test this hypothesis, we generated β 1 /β 2 /β 3 -adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance...
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