Search results for: Kazushige Dobashi

Items from 1 to 20 out of 20 results

article

Longitudinal changes in adiponectin multimer levels in preterm infants

Yuya Nakano, Kazuo Itabashi, Kazushige Dobashi, Katsumi Mizuno

Early Human Development > 2016 > 95 > C > 29-33

Preterm infants have altered adiponectin levels at term-equivalent age and have a higher risk of developing components of the metabolic syndrome in later life than term infants.To investigate the longitudinal changes in adiponectin levels in preterm infants and to compare the levels between term and preterm infants.A cohort study.The study subjects were 43 term infants and 42 preterm infants born...

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Accumulation of subcutaneous fat, but not visceral fat, is a predictor of adiponectin levels in preterm infants at term-equivalent age

Yuya Nakano, Kazuo Itabashi, Motoichiro Sakurai, Madoka Aizawa, more

Early Human Development > 2014 > 90 > 5 > 213-217

Preterm infants have altered fat tissue development, including a higher percentage of fat mass and increased volume of visceral fat. They also have altered adiponectin levels, including a lower ratio of high-molecular-weight adiponectin (HMW-Ad) to total adiponectin (T-Ad) at term-equivalent age, compared with term infants.The objective of this study was to investigate the association between adiponectin...

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Decreased plasma levels of brain-derived neurotrophic factor and its relationship with obesity and birth weight in obese Japanese children

Shunsuke Araki, Yukiyo Yamamoto, Kazushige Dobashi, Kohtaro Asayama, more

Obesity Research & Clinical Practice > 2014 > 8 > 1 > e63-e69

Brain-derived neurotrophic factor (BDNF) plays important roles in the central regulation of food intake and body weight control. However, little is known about the role of BDNF in childhood obesity.To investigate the relationship between plasma levels of BDNF and anthropometric factors, metabolic derangements due to obesity, adipocytokine levels and birth weight in obese Japanese children.Sixty-six...

article

Abdominal Aortic Intima-Media Thickness in Preschool Children Born Preterm

Takeshi Shimizu, Takanari Fujii, Junya Iwasaki, Yuya Nakano, more

Pediatric Cardiology > 2014 > 35 > 1 > 121-125

Recently aortic intima-media thickness (IMT) has been used as an earlier marker of preclinical atherosclerosis in high-risk children, such as those with type 1 diabetes mellitus and hypercholesterolemia. Children who were born preterm have an early elevation in insulin resistance, which may be a risk factor for metabolic syndrome in adulthood. However, there is no optimal marker of subsequent cardiovascular...

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Feeding choice has a gender‐associated effect on infant growth

Keiko Nagahara, Kazushige Dobashi, Kazuo Itabashi

Pediatrics International > 55 > 4 > 481 - 487

BackgroundAppropriate nutrition during childhood is important for preventing future development of lifestyle‐related diseases. The effect of feeding choice on infant growth in Japan is not known. MethodsData from 204 healthy schoolchildren (age, 6–9 years) were obtained retrospectively from their parents by questionnaires. Breast‐fed (BF) and formula‐fed (FF) groups were defined as those fed only...

article

Cord serum adiponectin is positively related to postnatal body mass index gain

Yuya Nakano, Kazuo Itabashi, Keiko Nagahara, Motoichiro Sakurai, more

Pediatrics International > 54 > 1 > 76 - 80

Background: The roles of adiponectin and leptin in the early stages of life are poorly understood. We previously studied longitudinal changes in these adipocytokines from birth to 12 months of age. The aim of this investigation was to evaluate the correlation between cord serum adipocytokine levels and postnatal growth by 3 years of age. Methods: A questionnaire was sent to obtain the general physical...

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Successful risperidone treatment for behavioral disturbances in Prader–Willi syndrome

Shunsuke Araki, Taro Ohji, Naoki Shiota, Kazushige Dobashi, more

Pediatrics International > 52 > 1 > e1 - e3

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Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children

Shunsuke Araki, Kazushige Dobashi, Yukiyo Yamamoto, Kohtaro Asayama, more

European Journal of Pediatrics > 2010 > 169 > 8 > 965-970

Oxidative stress is considered to be increased in obese subjects. However, the association of oxidative stress with visceral adiposity and adiponectin level is not fully understood in children. Forty-four obese Japanese children and adolescents, 28 boys and 16 girls, with median age of 9.9 years [5.2–13.8 years], and the 28 age-matched non-obese healthy controls, 15 boys and 13 girls, were enrolled...

article

Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus

Rinko Kawagoe, Yukiyo Yamamoto, Kazuyasu Kubo, Kazushige Dobashi, more

Regulatory Peptides > 2008 > 145 > 1-3 > 133-140

We examined the developmental change of GALP mRNA in male and female rat hypothalamus during postnatal day 1 to 60, using in situ hybridization histochemistry. Neuropeptide Y (NPY) and proopiomelanocortin (POMC) mRNA in the hypothalamus were also examined because they are important in the regulation of food intake. GALP mRNA was first detected in the arcuate nucleus (ARC) on day 8. GALP mRNA was gradually...

article

Hydroxymethylglutaryl–CoA reductase inhibitor inhibits induction of nitric oxide synthase in 3T3–L1 preadipocytes

Kazushige Dobashi, Shunsuke Araki, Kazuyasu Kubo, Rinko Kawagoe, more

Life Sciences > 2008 > 82 > 1-2 > 85-90

Preadipocytes are considered to play a role in adipose tissue inflammation in obesity. The purpose of this study was to determine whether hydroxymethylglutaryl–CoA reductase inhibitor (statin) modulates the nitric oxide (NO) production via inducible NO synthase (iNOS) in preadipocytes. Undifferentiated 3T3–L1 cells, a model of preadipocytes, significantly produced NO by the treatment with the combination...

article

N-acetylcysteine attenuates TNF-α induced changes in secretion of interleukin-6, plasminogen activator inhibitor-1 and adiponectin from 3T3-L1 adipocytes

Shunsuke Araki, Kazushige Dobashi, Kazuyasu Kubo, Yukiyo Yamamoto, more

Life Sciences > 2006 > 79 > 25 > 2405-2412

TNF-α is a key molecule in obesity-related metabolic disturbances. This study was designed to determine whether N-acetylcysteine (NAC), an antioxidant, prevents the activation of nuclear factor-κB (NF-κB) by exogenously administered TNF-α in adipocytes, and whether such change affects the production of adipocytokines. The treatment of well-differentiated 3T3-L1 cells with 20 mM of NAC significantly...

article

Postnatal developmental change of the gene expression of galanin-like peptide in rat hypothalamus

Rinko Kawagoe, Yukiyo Yamamoto, Kazushige Dobashi, Kohtaro Asayama, more

Frontiers in Neuroendocrinology > 2006 > 27 > 1 > 8

article

Comparison of two assays for fibroblast growth factor (FGF)-23

Nobuaki Ito, Seiji Fukumoto, Yasuhiro Takeuchi, Toshiyuki Yasuda, more

Journal of Bone and Mineral Metabolism > 2005 > 23 > 6 > 435-440

FGF-23 was recently shown to be involved in the development of several hypophosphatemic diseases, including X-linked hypophosphatemic rickets/osteomalacia (XLH) and tumor-induced rickets/osteomalacia (TIO). FGF-23 is processed between Arg¹⁷⁹ and Ser¹⁸⁰, and only full-length FGF-23 was shown to cause hypophosphatemia. Two assays for FGF-23 have been reported. One assay detects only full-length FGF-23...

article

Inhibition of peroxisomal functions due to oxidative imbalance induced by mistargeting of catalase to cytoplasm is restored by vitamin E treatment in skin fibroblasts from Zellweger syndrome-like patients

Yasusada Kawada, Mushfiquddin Khan, Ashish K. Sharma, Dinath B. Ratnayake, more

Molecular Genetics and Metabolism > 2004 > 83 > 4 > 297-305

Many of the peroxisomal diseases exhibit excessive oxidative stress leading to neurological alterations and dysfunction. The role of peroxisomal oxidative stress in cellular function was highlighted by the loss of metabolic functions in peroxisomes of mutant cell lines, where catalase is mistargeted to the cytoplasm, but restored to peroxisomes by genetic manipulation (Sheikh et al. [Proc. Natl. Acad...

article

Differential effects of cyclic AMP on induction of nitric oxide synthase in 3T3-L1 cells and brown adipocytes

Kazushige Dobashi, Kohtaro Asayama, Akira Shirahata

Free Radical Biology and Medicine > 2003 > 35 > 1 > 94-101

The aim of this study was to determine whether cyclic AMP (cAMP) pathways alter the nitric oxide (NO) production mediated by inducible NO synthase (iNOS) in adipocytes. The treatment of 3T3-L1 cells, a model of white adipocytes, with the combination of lipopolysaccharide (L), tumor necrosis factor-α (T), and interferon-γ (I) synergistically induced iNOS, leading to the production of NO. Enhancers...

article

Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney

Kazushige Dobashi, Inderjit Singh, John K. Orak, Kohtaro Asayama, more

Molecular and Cellular Biochemistry > 2002 > 240 > 1-2 > 9-17

Renal ischemia is of clinical interest because of its role in renal failure and also renal graft rejection. To evaluate the effect of the combination of N-acetylcysteine (NAC), a potent antioxidant, sodium nitroprusside (SNP), a nitric oxide donor, and phosphoramidon (P), an endothelin converting enzyme inhibitor, on tissue protection against ischemia-reperfusion injury, we studied the biochemical...

article

Troglitazone inhibits the expression of inducible nitric oxide synthase in adipocytes in vitro and in vivo - Study in 3T3-L1 cells and Otsuka Long-Evans Tokushima Fatty rats

Kazushige Dobashi, Kohtaro Asayama, Takaya Nakane, Koji Kodera, more

Life Sciences > 2000 > 67 > 17 > 2093-2101

The aim of this study was to determine the mechanism of troglitazone action on nitric oxide (NO) production via inducible NO synthase (iNOS) in adipocytes in vitro and in vivo. The treatment of 3T3-L1 adipocytes with the combination of lipopolysaccharide (LPS), tumor necrosis factor-α and interferon-γ synergistically induced de novo iNOS expression leading to enhanced NO production. The NO production...

article

Manganese superoxide dismutase in rat liver peroxisomes: Biochemical and immunochemical evidence

Avtar K. Singh, Kazushige Dobashi, Mahesh P. Gupta, Kohtaro Asayama, more

Molecular and Cellular Biochemistry > 1999 > 197 > 1-2 > 7-12

By using highly purified peroxisomes from rat liver, we have shown that peroxisomes contain manganese superoxide dismutase (MnSOD) activity and a 23 kDa protein immunoreactive with antibodies against purified mitochondrial MnSOD. Immunocytochemical studies have also revealed immunoreaction (immunogold) with MnSOD antibodies in mitochondria and peroxisomes. Studies of the intraperoxisomal localization...

article

Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion

Mahesh Gupta, Kazushige Dobashi, Eddie L. Greene, John K. Orak, more

Molecular and Cellular Biochemistry > 1997 > 176 > 1-2 > 337-347

The activities of rat hepatic subcellular antioxidant enzymes were studied during hepatic ischemia/reperfusion. Ischemia was induced for 30 min (reversible ischemia) or 60 min (irreversible ischemia). Ischemia was followed by 2 or 24 h of reperfusion. Hepatocyte peroxisomal catalase enzyme activity decreased during 60 min of ischemia and declined further during reperfusion. Peroxisomes of normal density...

article

Tissue differences in antioxidant enzyme gene expression in response to endotoxin

Bidyut Ghosh, Coral Dawn Hanevold, Kazushige Dobashi, John Kenneth Orak, more

Free Radical Biology and Medicine > 1996 > 21 > 4 > 533-540

The effect of endotoxin on antioxidant gene expression and antioxidant enzyme activity in homogenates of the heart, liver, and kidney from Sprague-Dawley rats was compared by quantitation of m-RNA and enzyme activities. Alterations in the message level for Cu-Zn superoxide dismutase (SOD), Mn SOD, and catalase varied with the tissue type, length of exposure to endotoxin, and dose of endotoxin. In...

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