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Contemporary infant cardiopulmonary bypass circuits require a blood prime. Blood, especially when stored, generates an inflammatory response, and may contribute to organ dysfunction following cardiopulmonary bypass. We determined whether using a miniaturized circuit and an asanguineous prime attenuated the post-bypass inflammatory response, and improved right ventricular and pulmonary function. ...
Introduction: In previous clinical trials with severely injured patients, we observed that resuscitation with a polymerized hemoglobin solution (PolyHb) compared to stored pRBCs reduced circulating plasma levels of pro-inflammatory cytokines IL-6 and IL-8 at 6-12 hours after injury. HO-1, the inducible isoform of the anti-oxidant protein heme-oxygenase, is present in most tissues and can be induced...
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