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Suppressor of cytokine signaling (SOCS) proteins are involved in the negative regulation of cytokine-induced STAT (signal transducers and activators of transcription) factor signaling. We cloned genomic regions of SOCS1 and SOCS2 genes and mapped these genes to chromosome 16p12–p13.1 and chromosome 12q21.3–q23 regions, respectively, by cytogenetic and radiation hybrid mapping. In addition, we mapped...
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is an arachidonic acid binding protein that has been shown to be critical in the biosynthesis of leukotrienes. We mapped the ALOX5AP gene to the chromosome 13q12 region by cytogenetic mapping, yeast artificial chromosome (YAC) pool screening, and radiation hybrid mapping. It was mapped to YAC contig WC13.2 by YAC pool screening with an unambiguous...
In a multicenter, double-blind study, 255 patients with mild asthma were randomly assigned to inhale albuterol on either a regular schedule (126 patients) or only as needed (129 patients). The primary outcome indicator was peak expiratory air flow measured in the morning. There were no clinically significant differences between the two groups. Thus, the authors concluded that inhaled albuterol...
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