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Activity-guided fractionation of methanol:chloroform (1:1) extract of Zataria multiflora Boiss was performed in order to investigate the active component(s) responsible for antinociceptive activity. Antinociceptive activity was evaluated using hot-plate and writhing tests. Morphine (10mg/kg, i.p.) and diclofenac (10mg/kg, i.p.) were used as positive controls. The methanol-chloroform (1:1) extract...