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Focused ultrasound (FUS)-induced with microbubbles (MBs) is a promising technique for noninvasive opening of the blood-brain barrier (BBB) to allow targeted delivery of therapeutic substances into the brain and thus the noninvasive delivery of gene vectors for CNS treatment. We have previously demonstrated that a separated gene-carrying liposome and MBs administration plus FUS exposure can deliver...
Glial cell line-derived neurotrophic factor (GDNF) is a potent agent for treating Parkinson's disease (PD). Microbubbles (MBs) have been exploited as a carrier for GDNF delivery with focused ultrasound (FUS) destruction. However, GDNF supplementation only relieves PD symptoms rather than cure it. Thus, design of an endogenous GDNF generative mechanism is an urgent concern for novel PD treatment. Here,...
Characterization of ultrasonic contrast agents (UCAs) destruction provides important information for the design of contrast-assisted perfusion imaging. In this paper, we proposed an acoustical method to demonstrate the relationship between different acoustic exposure conditions and the degree of UCAs destruction. The method also provides a simple and convenient way to determine the bubble destruction...
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