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Heat shock proteins (HSPs) play an important role in cell homeostasis and protect against cell damage. They were previously identified as key players in different ataxia models. HSF1 is the main transcription factor for HSP activation. HSF1-deficient mice (HSF1−/−) are known to have deficiencies in motor control test. However, little is known about effects of HSF1-deficiency on locomotor, especially...
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