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To correlate the pharmacological effects of the fixed herbal combination STW 5 (Iberogast ® ) containing nine extract components with its confirmed clinical efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco-2-cell model were used. The absorption rate of the extracts was determined by measuring characteristic...
We produced transgenic tobacco plants expressing the plastidic pyruvate, orthophosphate dikinase (PPDK) from the facultative Crassulacean acid metabolism plant Mesembryanthemum crystallinum. These transgenic plants had increased PPDK amounts in leaves and seeds. They produced more seeds per seed capsule and heavier seed capsules than the wildtype. When the enzyme was expressed in the cytosol by...
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