Search results for: CATIA GIOVANNINI

Items from 1 to 8 out of 8 results

article

Circulating CD8 lymphocytes predict response to atezolizumab–bevacizumab in hepatocellular carcinoma

Laura Gramantieri, Fabrizia Suzzi, Cristian Bassi, Lucilla D'Abundo, more

European Journal of Immunology > 54 > 2 > n/a - n/a

Due to the lack of biomarkers predictive of response to atezolizumab–bevacizumab, the standard of care for advanced HCC, we analyzed baseline and early on‐treatment variation of peripheral lymphocyte populations of 37 prospective patients treated by atezolizumab–bevacizumab and in 15 prospective patients treated by sorafenib or lenvatinib (TKIs). RNAseq analysis followed by RT‐PCR validation on patients‐derived...

article

Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, more

European Journal of Medicinal Chemistry > 2018 > 155 > C > 839-846

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to confront Alzheimer's disease (AD), this strategy has been scarcely investigated. To explore this promising line, a series of 5-amino-4-aryl-3,4,6,7,8,9-hexahydropyrimido [4,5-b]quinoline-2(1H)-thiones (tacripyrimidines)...

article

CDKN1C/P57 Is Regulated by the Notch Target Gene Hes1 and Induces Senescence in Human Hepatocellular Carcinoma

Catia Giovannini, Laura Gramantieri, Manuela Minguzzi, Francesca Fornari, more

The American Journal of Pathology > 2012 > 181 > 2 > 413-422

CDKN1C/P57 is a cyclin-dependent kinase inhibitor implicated in different human cancers, including hepatocellular carcinoma (HCC); however, little is known regarding the role of CDKN1C/P57 and its regulation in HCC. In this study, we show that the down-regulation of Notch1 and Notch3 in two HCC cell lines resulted in Hes1 down-regulation, CDKN1C/P57 up-regulation, and reduced cell growth. In line...

article

Selective ablation of Notch3 in HCC enhances doxorubicin’s death promoting effect by a p53 dependent mechanism

Catia Giovannini, Laura Gramantieri, Pasquale Chieco, Manuela Minguzzi, more

Journal of Hepatology > 2009 > 50 > 5 > 969-979

The functional roles of endogenous Notch3 and Notch1 for protecting human hepatocellular carcinoma (HCC) lines against doxorubicin-induced death have been investigated. We previously reported aberrant Notch3 and Notch4 up-regulation in HCC and we have extended these observations to include Notch1.Notch1 expression was assessed by immunohistochemistry and immunoblotting. Notch3 and Notch1 expression...

article

GADD45-α expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation

Laura Gramantieri, Pasquale Chieco, Catia Giovannini, Michela Lacchini, more

Human Pathology > 2005 > 36 > 11 > 1154-1162

Growth arrest and DNA damage 45-α (GADD45-α) is a nuclear protein involved in maintenance of genomic stability, DNA repair, and suppression of cell growth through interaction with nuclear elements, including cyclin-dependent kinase inhibitor 1A (CDKN1A) and PCNA. In this study, GADD45-α expression was assessed in 28 cases of hepatocellular carcinoma (HCC) and matched cirrhosis tissues, and correlated...

article

FIBROUS HAMARTOMA OF CORPUS CAVERNOSUM: A RARE CAUSE OF CONGENITAL PENILE CURVATURE ASSOCIATED WITH ERECTILE DYSFUNCTION

ALESSANDRO BERTACCINI, DEBORA MARCHIORI, CATIA GIOVANNINI, NUNZIO SALFI, more

The Journal of Urology > 2004 > 172 > 2 > 642-643

article

In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repair

Laura Gramantieri, Davide Trerè, Pasquale Chieco, Michela Lacchini, more

Journal of Hepatology > 2003 > 39 > 6 > 997-1003

Background: Proliferating cell nuclear antigen (PCNA) is a nuclear protein involved in DNA-synthesis and repair. During DNA-synthesis and repair the only active PCNA fraction is tightly bound to DNA. Similarly, during DNA-repair, a fraction of p21 colocalizes with PCNA in a detergent-insoluble form.Aim: The aim of the study was to analyze to what extent the presence of DNA-bound PCNA and p21 correlates...

article

Telomerase assay from ex vivo prostate biopsies

Alessandro Bertaccini, Catia Giovannini, Domenico Viola, Francesco Comerci, more

European Urology Supplements > 2002 > 1 > 1 > 119

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