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Runt‐related transcription factor 2 (RUNX2/Cbfa1) is the main regulatory gene controlling skeletal development and morphogenesis in vertebrates. It is located on chromosome 6p21 and has two functional isoforms (type I and type II) under control of two alternate promoters (P1 and P2). Mutations within RUNX2 are linked to Cleidocranial dysplasia syndrome (CCD) in humans. CCD is an autosomal skeletal...
Two mRNAs are transcribed from the extracellular matrix protein 1 gene (Ecm1): Ecm1a and an alternatively spliced Ecm1b. We studied Ecm1 mRNA expression and localization during endochondral bone formation and investigated the effect of recombinant human (rh) Ecm1a protein on organ cultures of embryonic mouse metatarsals. Of the two transcripts, Ecm1a mRNA was predominantly expressed in fetal metacarpals...
A secreted protein, Ecm1, specific for the clonal osteogenic stromal cell line MN7 was identified by 2D-SDS-PAGE (Mathieu et al, 1994, J. Bone Miner Res, 9, 903-913). The complete cDNA of the ECM1 gene has a length of 1.9 kb and codes for a protein of 559 amino acids. The Ecm1 mRNA is differentially spliced to a 1.5 Kb transcript. The 1.9 Kb mRNA is present in different tissues such as liver, lung...
We have used mouse fetal mandibular condyles as an in vitro model system to study chondro- and/or osteogenesis. Perinatal mouse mandibular condyles undergo chondrogenic differentiation in vivo, but switch to an osteogenic differentiation pathway when explanted in vitro.With the aim of isolating novel transcripts that are expressed during chondroand osteogenesis, a cDNA library from in vitro cultured...
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