Search results for: Alison D. Findlay

Items from 1 to 7 out of 7 results

article

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor

Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D. Findlay, more

Insulin‐regulated aminopeptidase (IRAP) is an enzyme with important biological functions and the target of drug‐discovery efforts. We combined in silico screening with a medicinal chemistry optimization campaign to discover a nanomolar inhibitor of IRAP based on a pyrazolylpyrimidine scaffold. This compound displays an excellent selectivity profile versus homologous aminopeptidases, and kinetic analysis...

article

The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts

Heidi Schilter, Carmen Z. Cantemir-Stone, Vladimir Leksa, Anna Ohradanova-Repic, more

Immunology Letters > 2015 > 165 > 2 > 90-101

Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a progressive decline in lung function which can be attributed to excessive scarring, inflammation and airway remodelling. Mannose-6-phosphate (M6P) is a strong inhibitor of fibrosis and its administration has been associated with beneficial effects in tendon repair surgery as well as nerve repair after injury. Given this promising...

article

The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions: Application to the Synthesis of 2 H -Chromenes, Coumarins, Benzofurans, and Dihydroquinolines

Rajeev S. Menon, Alison D. Findlay, Alex C. Bissember, Martin G. Banwell

The Journal of Organic Chemistry > 2009 > 74 > 22 > 8901 - 8903

article

A Chemoenzymatic Total Synthesis of (+)-Amabiline

Alison D. Findlay, Martin G. Banwell

Organic Letters > 2009 > 11 > 14 > 3160 - 3162

article

Total synthesis of pteridic acids A and B

Ian Paterson, Edward A. Anderson, Alison D. Findlay, Christopher S. Knappy

Tetrahedron > 2008 > 64 > 21 > 4768-4777

A convergent synthesis of pteridic acids A and B, epimeric spiroacetal polyketides with potent plant growth promoter properties, is described. The use of boron aldol methodology efficiently achieved the stereocontrolled construction of advanced C1–C11 and C12–C16 subunits, which were coupled to generate a linear (Z)-enone precursor that underwent spiroacetalization with HF·pyridine, providing pteridic...

article

Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia

Ian Paterson, Alison D. Findlay, Gordon J. Florence

Tetrahedron > 2007 > 63 > 26 > 5806-5819

Using conformational analysis and biogenetic considerations, a revised configurational assignment for the cytotoxic marine macrolide dolastatin 19 is proposed, together with its validation by completion of the first total synthesis. Key features of the highly stereocontrolled route include an asymmetric vinylogous Mukaiyama aldol reaction to simultaneously install both the remote C13 stereocenter...

article

Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19 ^†

Ian Paterson, Alison D. Findlay, Gordon J. Florence

Organic Letters > 2006 > 8 > 10 > 2131 - 2134

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Search results for: Alison D. Findlay

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor

The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts

The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions: Application to the Synthesis of 2 H -Chromenes, Coumarins, Benzofurans, and Dihydroquinolines

A Chemoenzymatic Total Synthesis of (+)-Amabiline

Total synthesis of pteridic acids A and B

Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia

Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19 †

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Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19 ^†