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Parathyroid hormone (PTH) secretion is stimulated by low extracellular calcium (Ca 2+ ) in association with a reduction in cyosolic Ca 2+ , indicating that this cell type does not conform to classical models of stimulus-secretion coupling. We used the phorbol ester TPA (12-O-tetradecanoyl phorbol 13-acetate), which directly activates protein kinase C, to investigate the possible...