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Pancreatic cancer is an aggressive disease a 5-year-survival rate less than 7%. To improve the patient overall survival, recent developments in pancreatic cancer research have been targeting various components of the tumor microenvironment such as the extracellular matrix, blood vessels and immune cells. We hypothesize that targeted therapies will affect the biomechanics of the tumor microenvironment...
With the development of micron-scale imaging techniques, capillaries can be conveniently visualized using methods such as two-photon and whole mount microscopy. However, the presence of background staining, leaky vessels and the diffusion of small fluorescent molecules can lead to significant complexity in image analysis and loss of information necessary to accurately quantify vascular metrics. One...
HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. In fission yeast, two HP1 homologs, Swi6 and Chp2, function in heterochromatic gene silencing, but their relative contribution to silencing remains unknown. Here we show that Swi6 and Chp2 exist in nonoverlapping complexes and make...
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