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Myeloma cells specifically localize in the bone marrow and rarely circulate in blood. To study whether this immobilization could be partially explained by the presence of constitutively activated integrins, particularly α4β1, we used the activation reporter HUTS-21 anti-β1 mAb. These analyses showed that β1 integrins on myeloma cells were moderately active and could be upregulated similarly to integrins...
The structure-function relationship of the human integrin VLA-4 (α4/β1; CD49d/CD29), has been studied in the human B-cell line Ramos by immunochemical and functional analysis. Ramos cells expressed the 150-kDa non-proteolyzed form of the α4 chain, which could be digested upon mild trypsin treatment to generate the 80- and 65-kDa proteolyzed forms, as well as α4 polypeptides of 55 and 50 kDa. In addition,...
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