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Ensuring genetic stability is a prerequisite for live attenuated influenza vaccine (LAIV). This study describes the results of virus shedding and clinical isolates’ testing of Phase I clinical trials of Russian LAIVs against potentially pandemic influenza viruses in healthy adults.Three live attenuated vaccines against potentially pandemic influenza viruses, H2N2 LAIV, H5N2 LAIV and H7N3 LAIV, generated...
Reassortment of influenza viruses in nature has been well documented. Genetic reassortment plays a key role in emergence of new influenza A strains, including pandemic viruses. Permissive host can be simultaneously coinfected with multiple influenza viruses. During genetic reassortment gene segments are exchanged between parental viruses that may lead to some enhancement of virulence of reassortant...
In order to deepen the knowledge and further advance theory on business process management (BPM) on small- to medium sized enterprises (SMEs), the analysis of the impact of information and communication technologies (ICT) on SMEs in emerging countries was conducted. The paper seeks to develop the conception of adaptive business process management on SMEs in the developing countries.
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