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The role of adenosine in suppressing synaptic responses during prolonged moderate hypoxia was examined in rat hippocampal slices. The intrahypoxic loss of evoked synaptic responses could be reversed partially by an antagonist of the A 1 type adenosine receptor during an entire hour of hypoxia. These findings indicate that the capacity to express synaptic transmission exists during prolonged...
The propensity of neurons to undergo profound and precipitous depolarization is believed to contribute to their characteristic vulnerability to hypoxic injury. The length of time a neuron spends in a depolarized state following hypoxic depolarization (HD) is a critical determinant of the extent of irreversible cell damage. It is less clear, however, what the effects of moderate hypoxia are when HD...
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