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To monitor the circulation of clones among the most frequent phenotypes of Neisseria meningitidis isolated from sporadic cases in Italy in recent years. N. meningitidis strains sent to the reference laboratory for meningococcal meningitis of the istituto Superiore di Sanità were typed for serogroup, serotype and serosubtype, and chromosomal DNAs were analyzed by pulsed-field gel electrophoresis...
Over the last few years our laboratory has been assessing the consistency of production of different batches of acellular pertussis vaccines to be marketed in Italy. Central to this is immunogenicity assay of the lots under control compared with those of a reference vaccine with documented clinical efficacy.However, the current assays based on the assessment of antibody (Ab) response in the mouse...
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