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Serum dipeptidyl peptidase IV (DPPIV) activity is decreased in some individuals with ACE inhibitor–associated angioedema. ACE and DPPIV degrade substance P, an edema-forming peptide. The contribution of impaired degradation of substance P by DPPIV to the pathogenesis of ACE inhibitor–associated angioedema is unknown.We sought to determine whether DPPIV deficiency results in increased edema formation...