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The neutrophil is an important effector cell of the host response to sepsis. Tumor necrosis factor-α (TNF-α), a cytokine mediator of the septic response, is rapidly released following endotoxemia or gram-negative bacteremia. Interleukin-6 (IL-6) is another cytokine mediator of the host response to sepsis whose role is less well understood than that of TNF-α. It is known to be elevated in gram-negative...