Search results for: Zheng-jiong Lin

Items from 1 to 7 out of 7 results

article

Functions, structures and Triton X-100 effect for the catalytic subunits of heterodimeric phospholipases A2 from Vipera nikolskii venom

Wei Gao, Vladislav G. Starkov, Zi-xuan He, Qi-hai Wang, more

Toxicon > 2009 > 54 > 6 > 709-716

Phospholipases A ₂ (PLA ₂ s) from snake venoms have diverse pharmacological functions including neurotoxicity, and more studies are necessary to understand relevant mechanisms. Here we report the different crystal structures for two enzymatically active basic subunits (HDP-1P and HDP-2P) of heterodimeric neurotoxic PLA ₂ s isolated from Vipera nikolskii venom. Structural comparisons...

article

Structural and functional analysis of natrin, a venom protein that targets various ion channels

Feng Wang, He Li, Ming-na Liu, Hui Song, more

Biochemical and Biophysical Research Communications > 2006 > 351 > 2 > 443-448

Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68Å. Our electrophysiological...

article

Structure of a cardiotoxic phospholipase A ₂ from Ophiophagus hannah with the ''pancreatic loop''

Hai-long Zhang, Su-juan Xu, Qiu-yan Wang, Shi-ying Song, more

Journal of Structural Biology > 2002 > 138 > 3 > 207-215

The crystal structure of an acidic phospholipase A ₂ from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-Å resolution to a crystallographic R factor of 20.5% (R _f _r _e _e =23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual ''pancreatic loop.'' The conformation of the loop is well defined and different from those...

article

Structure of Apo-glyceraldehyde-3-phosphate Dehydrogenase from Palinurus versicolor

Yue-quan Shen, Jun Li, Shi-ying Song, Zheng-jiong Lin

Journal of Structural Biology > 2000 > 130 > 1 > 1-9

d-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) shows cooperative properties for binding coenzymes. The structure of apo-GAPDH from Palinurus versicolor has been solved at 2.0 Å resolution by X-ray crystallography. The final model gives a crystallographic R factor of 0.178 in the resolution range 8 to 2 Å. The structural comparison with holo-GAPDH from the same species reveals a conformational...

article

Structure of active site carboxymethylated d-glyceraldehyde-3-phosphate dehydrogenase from Palinurus versicolor

Shi-ying Song, Yi-bin Xu, Zheng-jiong Lin, Chen-lu Tsou

Journal of Molecular Biology > 1999 > 287 > 4 > 719-725

The structure of active site carboxymethylated d-glyceraldehyde-3-phosphate dehydrogenase from Palinurus versicolor was determined in the presence of coenzyme NAD ⁺ at 1.88 A resolution with a final R-factor of 0.175. The structure refinement was carried out on the basis of the structure of holo-GAPDH at 2.0 A resolution using the program XPLOR. The carboxymethyl group connected to Cys149...

article

Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from Agkistrodon halys pallas

Liang Tang, Yuan-cong Zhou, Zheng-jiong Lin

Journal of Molecular Biology > 1998 > 282 > 1 > 1-11

The crystal structure of agkistrodotoxin containing eight copies of molecules in the asymmetric unit has been determined at 2.8 A resolution to a crystallographic R factor of 0.207 by the molecular replacement technique. Two spatially adjacent regions of agkistrodotoxin molecule, turn 55-61 and stretch 85-91, are remarkably different from those of non-neurotoxic isoforms in conformation and electrostatic...

article

Crystal Structure of an Acidic Phospholipase A ₂ from the Venom ofAgkistrodon halyspallas at 2.0 Å Resolution

Xiao-qiang Wang, Jian Yang, Lu-lu Gui, Zheng-jiong Lin, more

Journal of Molecular Biology > 1996 > 255 > 5 > 669-676

The crystal structure of acidic phospholipase A ₂ from the venom ofAgkistrodon halyspallas has been determined by molecular replacement at 2.0 Å resolution to a crystallographicR-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A ₂ species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region...

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Keywords

CRYSTAL STRUCTURE (4)
PHOSPHOLIPASE A2 (2)
KING COBRA PHOSPHOLIPASE A 2 (1)
PHOSPHOLIPASE A 2 ; PLATELET AGGREGATION INHIBITOR; CRYSTAL STRUCTURE; MOLECULAR REPLACEMENT; CRYSTALLOGRAPHIC REFINEMENT (1)
ACTIVE SITE MODIFICATION (1)
AGKISTRODOTOXIN (1)
BLOCKER (1)
CARDIOTOXIN (1)
CONFORMATIONAL CHANGE (1)
COOPERATIVITY. (1)
CRISP (1)
GAPDH, DEHYDROGENASE (1)
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (1)
HALF-OF-SITE REACTIVITY (1)
ION CHANNEL (1)
MOLECULAR REPLACEMENT (1)
MOLECULAR SYMMETRY (1)
MYOTOXIN (1)
NATRIN (1)
NEUROTOXIC SITE (1)
NEUROTOXICITY (1)
PRESYNAPTIC NEUROTOXIN (1)
TRITON X-100 (1)
VIPER VENOM (1)
X-RAY STRUCTURE (1)
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Journal

Journal of Molecular Biology (3)
Journal of Structural Biology (2)
Biochemical and Biophysical Research Communications (1)
Toxicon (1)

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Search results for: Zheng-jiong Lin

Functions, structures and Triton X-100 effect for the catalytic subunits of heterodimeric phospholipases A2 from Vipera nikolskii venom

Structural and functional analysis of natrin, a venom protein that targets various ion channels

Structure of a cardiotoxic phospholipase A 2 from Ophiophagus hannah with the ''pancreatic loop''

Structure of Apo-glyceraldehyde-3-phosphate Dehydrogenase from Palinurus versicolor

Structure of active site carboxymethylated d-glyceraldehyde-3-phosphate dehydrogenase from Palinurus versicolor

Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from Agkistrodon halys pallas

Crystal Structure of an Acidic Phospholipase A 2 from the Venom ofAgkistrodon halyspallas at 2.0 Å Resolution

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Structure of a cardiotoxic phospholipase A ₂ from Ophiophagus hannah with the ''pancreatic loop''

Crystal Structure of an Acidic Phospholipase A ₂ from the Venom ofAgkistrodon halyspallas at 2.0 Å Resolution