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Three possible effector fates await the naïve follicular B cell following antigen stimulation in thymus-dependent reactions. Short-lived plasma cells produce an initial burst of germline-encoded protective antibodies, and long-lived plasma cells and memory B cells arise from the germinal center and function to enhance and sustain the humoral immune response. The inherent B-cell receptor affinity of...
Long-term humoral immunity elicited by pathogens and vaccines alike relies upon the generation of both memory B cells (B mem ) and long-lived plasma cells (PCs). Virtually all vaccine formulations induce the concomitant emergence of both B mem and PCs, suggesting that the emergence of these two differentiated B cells subsets is commonly controlled. Evidence presented shows specific...
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