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There is growing evidence that schizophrenia (SZ) and bipolar disorder (BD) overlap significantly in risk factors, neurobiological features, clinical presentations, and outcomes. SZ is characterized by well documented gray matter (GM) abnormalities in multiple frontal, temporal and subcortical structures. Recent voxel-based morphometry (VBM) studies and meta-analyses in BD also report GM reductions...
Augmentation of selective serotonin reuptake inhibitors (SSRIs) therapy by the 5-HT 1A receptor agent pindolol may reduce the delay between initiation of antidepressant treatment and clinical response. This hypothesis is based on the ability of pindolol to block 5-HT 1A autoreceptors in the dorsal raphe nuclei (DRN) and to potentiate the increase in 5-HT transmission induced...
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