Search results for: J. Lafond

Items from 1 to 20 out of 24 results

article

Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2

C. Toudic, X. Elisseeff, A. Vargas, Y. Xiao, more

Placenta > 2017 > 57 > C > 301-302

article

Screening for pre‐eclampsia early in pregnancy: performance of a multivariable model combining clinical characteristics and biochemical markers

Y Giguère, J Massé, S Thériault, E Bujold, more

BJOG: An International Journal of Obstetrics & Gynaecology > 122 > 3 > 402 - 410

ObjectiveTo investigate the performance of a multivariable model combining a priori clinical characteristics and biomarkers to detect, early in pregnancy, women at higher risk of developing pre‐eclampsia (PE). DesignNested case–control study. SettingUniversity medical centre, Quebec, Canada (CHU de Québec). PopulationA total of 7929 pregnant women recruited between 10 and 18 weeks of gestation...

article

MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion

C. Toufaily, A. Vargas, M. Lemire, J. Lafond, more

Placenta > 2013 > 34 > 1 > 85-88

The syncytiotrophoblast is formed at the placental periphery through cytotrophoblast fusion, which depends on Human Endogenous Retrovirus-encoded Envelope proteins Syncytin-1 and Syncytin-2. In the current study, the role of Major Facilitator Superfamily Domain Containing 2A (MFSD2a), the Syncytin-2 receptor, in trophoblast fusion and its expression in normal vs. pre-eclampsia placentas were studied...

article

Investigation of the clinical utility of the measurement of clinical and biochemical markers at late mid-term of pregnancy to identify women who will develop preeclampsia within a few weeks

J. Massé, Y. Giguère, S. Thériault, M. Charland, more

Clinical Biochemistry > 2012 > 45 > 13-14 > 1114

article

Screening for preeclampsia early in pregnancy in a population with a low prevalence of the syndrome: Validation of clinical and biochemical markers based on a multivariate regression analysis

Sébastien Thériault, Y. Giguère, J. Massé, M. Charland, more

Clinical Biochemistry > 2012 > 45 > 13-14 > 1120-1121

article

OS090. Performance of candidate clinical and biochemical markers in screening early in pregnancy to detect women at high risk to develop preeclampsia

J.-C. Forest, J. Massé, E. Bujold, F. Rousseau, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2012 > 2 > 3 > 227

The advent of early preventive measures, such as low-dose aspirin targeting women at high risk of preeclampsia (PE), emphasizes the need for better detection. Despite the emergence of promising biochemical markers linked to the pathophysiological processes, systematic reviews have shown that, until now, no single tests fulfill the criteria set by WHO for biomarkers to screen for a disease. However,...

article

PP054. Predicting preeclampsia at late mid-term pregnancy before occurrence of clinical symptoms: Clinical utility of biomarkers and clinical parameters in a low-risk population

J.-C. Forest, J. Massé, E. Bujold, J. Lafond, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2012 > 2 > 3 > 271

Despite research efforts and healthcare improvement, preeclampsia (PE) continues to be a leading cause of maternal and fetal morbidity and mortality. Early identification of women at risk of developing PE is the most promising approach to implement preventive measures such as low-dose aspirin to reduce negative outcomes. However, it is still relevant to evaluate pregnant women to detect PE before...

article

Stability of reference proteins in human placenta: General protein stains are the benchmark

D. Lanoix, J. St-Pierre, A.-A. Lacasse, M. Viau, more

Placenta > 2012 > 33 > 3 > 151-156

The stability of reference proteins in semi-quantitative Western blot experiments in normal and diseased placenta has never been studied. This study aims to determine the stability of five reference proteins and two general protein stains in placentas from preeclampsia, gestational diabetes mellitus and matched control pregnancies. The stability of the reference proteins was analysed using indicators...

article

Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents

M.F. Young, E. Pressman, M.L. Foehr, T. McNanley, more

Placenta > 2010 > 31 > 11 > 1010-1014

To elucidate the role of maternal and neonatal iron status on placental transferrin receptor (TfR) expression.Ninety-two healthy pregnant adolescents (ages 14–18 years) were followed across pregnancy. Maternal iron status (hemoglobin, hematocrit, serum ferritin, TfR, and total body iron) was assessed in mid-gestation (21–25 wks) and at delivery in the mother and neonate. Placental TfR protein expression...

article

Importance of ΩV-3 fatty acids on developmental programming of insulin resistance, hyperlipidemia and nonalcoholic steatohepatitis in psammomys obesus

E. Grenier, E. Ziv, E. Delvin, L. Leduc, more

Canadian Journal of Diabetes > 2009 > 33 > 1 > 54

article

PP2 Regulates Human Trophoblast Cells Differentiation by Activating p38 and ERK1/2 and Inhibiting FAK Activation

G. Daoud, F. Le bellego, J. Lafond

Placenta > 2008 > 29 > 10 > 862-870

Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutrients from the maternal circulation. This latter function depends on multinucleated, terminally differentiated syncytiotrophoblasts. In vitro, freshly isolated cytotrophoblast cells differentiate spontaneously into syncytiotrophoblast in the presence of fetal bovine serum (FBS). We have previously showed...

article

Induction of Trophoblast Cell Fusion by a Protein Tyrosine Phosphatase Inhibitor

A. Vargas, J. Moreau, F. Le Bellego, J. Lafond, more

Placenta > 2008 > 29 > 2 > 170-174

In the placenta, trophoblast cell fusion leads to the formation of the syncytiotrophoblast, which plays an essential role in the diffusion of nutrients and hormones from the mother to the fetus. Different protein tyrosine kinases are involved in the modulation of this biological process. Herein, we investigated the impact of a protein tyrosine phosphatase (PTP) inhibitor (bpV[pic]) on trophoblast...

article

Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits

C. Marseille-Tremblay, A. Gravel, J. Lafond, C. Mounier

Life Sciences > 2007 > 81 > 9 > 772-778

Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These changes take place to support fetal growth and development, and modifications of these maternal concentrations may influence lipids and cholesterol synthesis in the dam, fetus and placenta. Administration of a 0.2% enriched cholesterol diet (ECD) during rabbit gestation significantly increased cholesterol and triglyceride...

article

Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI

M. Ethier-Chiasson, A. Duchesne, J.-C. Forest, Y. Giguère, more

Biochemical and Biophysical Research Communications > 2007 > 359 > 1 > 8-14

Maternal hyperlipidemia is a characteristic feature during pregnancy, it has been reported that modification of the maternal lipid profile can induce disturbance during pregnancy. In this study, we evaluated the impact of maternal lipid profile on the placental protein expression of two major receptors in cholesterol metabolism, the low density lipoprotein receptor (LDLr) and the scavenger receptor...

article

Centres de ressources et de compétence de la mucoviscidose et réseaux de soins : la contribution des familles et des associations

S. Ravilly, M.C. Wolfrom, A. Lazarevitch, C. Marot, more

Archives de pediatrie > 2005 > 12 > 6 > 658-660

article

Very low level environmental exposure to lead and prolactin levels during pregnancy

L. Takser, D. Mergler, J. Lafond

Neurotoxicology and Teratology > 2005 > 27 > 3 > 505-508

Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the relationships between blood Pb concentration and serum PRL levels in 101 pregnant women...

article

Blood manganese content at birth and cord serum prolactin levels

L. Takser, D. Mergler, S. de Grosbois, A. Smargiassi, more

Neurotoxicology and Teratology > 2004 > 26 > 6 > 811-815

Manganese (Mn) is both an essential element and, at a high dose, a potent neurotoxin that can interact with dopaminergic neurotransmission. Plasma prolactin (PRL), an indirect indicator of dopaminergic functioning, has been shown to vary with Mn exposure in adults, but little is known about this relation in the developing brain. The objective of this study was to examine the relations between maternal...

article

Differential Expression of Membrane and Soluble Adenylyl Cyclase Isoforms in Cytotrophoblast Cells and Syncytiotrophoblasts of Human Placenta

R. Bernatchez, L. Belkacemi, E. Rassart, G. Daoud, more

Placenta > 2003 > 24 > 6 > 648-657

Adenylyl cyclase (AC) activity is ubiquitous in mammalian cells, and various forms of this enzyme exist that widely differ with regard to tissue distribution, abundance, and modes of regulation. Human placenta is made, among others, of cytotrophoblast cells and syncytiotrophoblasts. This latter is a polynucleate structure that originates from the differentiation of proliferative mononucleated cytotrophoblast...

article

P111 Sante publique - Education sanitaire - Environnement therapeutique Role de l'association vaincre la mucoviscidose dans la formation des parents

S. Ravilly, M. Bouquet-Martinez, S. Zeller, A. Marenco, more

Archives de pediatrie > 2003 > 10 > Supplement 1 > s306

article

Characteristics of Calcium Uptake by BeWo Cells, a Human Trophoblast Cell Line

R. Moreau, L. Simoneau, J. Lafond

Placenta > 2001 > 22 > 8-9 > 768-775

Placental transfer of maternal calcium (Ca²⁺) is a crucial process for fetal development although the biochemical mechanisms responsible for this transfer are largely unknown. We have investigated the characteristics of Ca²⁺uptake by the human placental trophoblast cell line BeWo. The kinetics studies revealed an active extracellular Ca²⁺uptake by BeWo cells, which was rapid in the first 2min (initial...

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Search results for: J. Lafond

Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2

Screening for pre‐eclampsia early in pregnancy: performance of a multivariable model combining clinical characteristics and biochemical markers

MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion

Investigation of the clinical utility of the measurement of clinical and biochemical markers at late mid-term of pregnancy to identify women who will develop preeclampsia within a few weeks

Screening for preeclampsia early in pregnancy in a population with a low prevalence of the syndrome: Validation of clinical and biochemical markers based on a multivariate regression analysis

OS090. Performance of candidate clinical and biochemical markers in screening early in pregnancy to detect women at high risk to develop preeclampsia

PP054. Predicting preeclampsia at late mid-term pregnancy before occurrence of clinical symptoms: Clinical utility of biomarkers and clinical parameters in a low-risk population

Stability of reference proteins in human placenta: General protein stains are the benchmark

Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents

Importance of ΩV-3 fatty acids on developmental programming of insulin resistance, hyperlipidemia and nonalcoholic steatohepatitis in psammomys obesus

PP2 Regulates Human Trophoblast Cells Differentiation by Activating p38 and ERK1/2 and Inhibiting FAK Activation

Induction of Trophoblast Cell Fusion by a Protein Tyrosine Phosphatase Inhibitor

Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits

Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI

Centres de ressources et de compétence de la mucoviscidose et réseaux de soins : la contribution des familles et des associations

Very low level environmental exposure to lead and prolactin levels during pregnancy

Blood manganese content at birth and cord serum prolactin levels

Differential Expression of Membrane and Soluble Adenylyl Cyclase Isoforms in Cytotrophoblast Cells and Syncytiotrophoblasts of Human Placenta

P111 Sante publique - Education sanitaire - Environnement therapeutique Role de l'association vaincre la mucoviscidose dans la formation des parents

Characteristics of Calcium Uptake by BeWo Cells, a Human Trophoblast Cell Line

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