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Herpesvirus thymidine kinases (TK) phosphorylate a wide range of nucleoside analogs resulting in activation of certain antiherpes drugs. The TKs are also of growing interest as targets for preventing recurrent herpetic infections. TKs from Herpes simplex virus types 1 and 2 (HSV1,2) are potently inhibited by N 2 -phenylguanines substituted in the phenyl ring and/or the 9 position of the...