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Aim The present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes. Methods Twenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60 min) submaximal cardiopulmonary...
It is well documented that intracellular calcium levels are elevated in Duchenne muscular dystrophy and in the mdx mouse model. We have previously used manganese enhanced magnetic resonance imaging (MEMRI) a technique which utilizes the T1 weighted contrast enhancing properties of Mn2+ as an in vivo marker for Ca2+ uptake in mdx and sgcd−/− myocardium. Here we have measured Mn2+ uptake in the pectoral...
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease that affects approximately l in 3500 male births. We describe animal models of DMD with special reference to the mdx mouse. We also describe some of the standard operating procedures (SOPs) developed by the TREAT-NMD neuromuscular network (http://www.treat-nmd. eu/) for assessment of the mdx mouse, with a focus on techniques...
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