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Valorphin, an endogenous opioid-like hemoglobin fragment, is cytotoxic for L929 and K562 tumor cells in 10 -7 -10 -13 M concentration range. Because cytolytic effects induced by valorphin in K562 cells are inhibited by naloxone, opioid receptors should be involved in induction of valorphin-mediated tumor cell death. Three distinct cytolytic processes, differing in the...
Objective: Cytolytic activity of TNF was analysed at L929 and K562 tumor cell lines. Methods: TNF-mediated cytotoxicity was studied within 10 -6 -10 -17 M concentration range after 18 h of incubation with target cells. Results: TNF caused reliable cytotoxicity values in both cell lines, while L929 cells were more sensitive to cytolytic action of the protein than K562...
Cytolytic activity of Met-enkephalin, an endogenous opioid peptide, was studied within the 10 -7 -10 -17 M concentration range in K562 human erythroid leukemia cells. Cytolytic activity was determined by the trypan blue inclusion method after 13, 15 and 18 h of Met-enkephalin co-incubation with target cells. Discrete maxima of cytolytic activity were detected at concentrations...
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