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Hepatitis C virus (HCV) is remarkable for its ability to establish persistent infection. Studies suggest that HCV core protein modulates immune responses to viral infection and can bind Fas receptor in vitro. To further examine the role of HCV core protein in Fas signaling, full-length (aa 1-192) and truncated (aa 1-152) HCV core proteins were expressed in Jurkat lymphocytes and cells were assayed...
Ligand-induced PDGF-type β receptor (PDGFβ-R) autophosphorylation is profoundly suppressed in cells transformed by activated p21 Ras . We report here that the integrity of the actin cytoskeleton is a critical regulator of PDGFβ-R function in the presence of p21 Ras . Morphological reversion of Balb cells expressing a constitutively activated p21 Ras , with re-formation of actin...
Hepatitis C virus (HCV) is a major human pathogen causing mild to severe liver disease worldwide and is remarkably efficient at establishing persistent infections. Previously, we have shown that the core protein has an immunomodulatory function including the suppression of T lymphocyte responses to viral infection. To investigate the underlying mechanism for the role of core protein in immune modulation,...
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