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Evaluation of a non-synonymous mutation associated with dihydropyrimidine dehydrogenase (DPD) deficiency.DPD enzyme analysis, mutation analysis and molecular dynamics simulations based on the 3D-model of DPD.The substitution Lys63Glu is likely to affect the FAD binding pocket within the DPD protein and contributes to a near-complete DPD deficiency in a patient with developmental retardation.Like other...