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Host defence peptides (HDP), including the defensins and hCAP‐18, function as part of the innate immune defences, protecting the host epithelia from microbial attachment and invasion. Recurrent acute tonsillitis (RAT), in which patients suffer repeated symptomatic tonsil infections, is linked to Streptococcus pyogenes, a group A streptococcus, and may reflect the impaired expression of such peptides...
This study examined the electrical properties and Na + transport function of a porcine trophectoderm cell line, TE1, which forms a polarized epithelium in culture. Specifically, the capacity of TE1 cells to generate a transepithelial potential difference, and to modify selectively the Na + , K + and Cl − ionic composition of medium in the apical and basolateral compartments,...
The relationship between the P-glycoprotein-mediated vinblastine secretion and cell-swelling activated Cl - secretion (conductance) in intact epithelial layers of human colonic adenocarcinoma T 84 cells has been investigated. Whereas vinblastine secretion is effectively inhibited by 100 μM 1,9-dideoxy-forskolin, volume-stimulated Cl - secretion is unaffected. In contrast,...
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