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To compare the anti-nociceptive effects of extradural xylazine, fentanyl and a xylazine–fentanyl combination in sheep, and to measure the cardiopulmonary effects of the xylazine–fentanyl combination. Prospective, randomized study. Twenty-five half-merino ewes 2–4 years of age and body mass 54.2 ± 1.1 kg. Six sheep in group 1 received 0.2 mg kg−1 xylazine by extradural injection, six in group...