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The heart is the most important natural realtime system and its interaction with an implantable artificial pacemaker make for a perfect example of a Cyber-Physical System. The increasing complexity in implantable cardiac device software has been responsible, in part, for the surge in device recalls due to firmware problems. To ensure the safety and efficacy of the device, the device's software has...
The perineuronal net (PN), a component of the neural extracellular matrix (ECM), is a dynamic structure whose expression decreases following diminished physiological activity. Here, we analyzed the effects of increased neuronal activity on the development of aggrecan, a component of the PN, in the hippocampus. We show aggrecan expression to be prominent around parvalbumin (PV) interneurons in the...
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