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Tumor necrosis factor-α (TNF-α)-induced proliferation of cancer cell line MDAH 2774 was significantly suppressed by treating the cells with saxatilin, a snake venom disintegrin. The suppressed proliferation was found to be associated with the level of interleukin-8 (IL-8) expression in the cells. TNF-α-induced IL-8 promoter activation that is inhibited by saxatilin treatment was dependent on activating...
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