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Objectives: The IL-1 system has been shown to play a crucial role in embryonic implantation; its components IL-1β, IL-1 receptor type (IL-1R tI) and IL-1 receptor antagonist (IL-1ra) protein- and mRNA are present in preimplantation embryos and maternal endometrium as well as in fallopian tubes in several species including humans. Our objective was to detect IL-1β, IL-1ra and IL-1R tI mRNA in single...
Objectives: Interleukin-1 (IL-1) is expressed in human endometrium and has been shown to play an integral role in local cellular interactions during embryonic implantation. In addition, the matrix metalloproteinase (MMPs) and their natural inhibitors, the tissue inhibitor of metalloproteinases (TIMPs) are crucial in tissue remodeling during implantation through in vitro trophoblast penetration in...